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KMID : 0371919880010010085
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Journal of Wonju College of Medicine
1988 Volume.1 No. 1 p.85 ~ p.93
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The Effect of Calcium Antagonist and Potassium Concentrations in the Cardioplegic Solution on the Recovery of Myocardial Function after Ischemic Cardiac Arrest
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Abstract
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High potassium crystalloid cardioplegia is a widely accepted procedure to enhance myocardiol protection from ischemic injuries associated with open hearts surgery. To determine whether addition of verapamil to the cardioplegic solution and high concentration of potassium in the solution can produce satisfactory myocardial protection during ischemia, 105 isolated rat hearts perfused by modified Langendorff technique were studied.
St. Thomas hospital cardioplegic solution was selected as a standard high potassium (16 mEq/L of K^(+) crystalloid cardioplegic solution. Four kinds of cardioplegic solutions were made by modifying the composition, and addition of verapamil, and lowering the concentration of potassium (4 mEq/L).
By changing the cooling temperature of myocardium and aorta-cross-clamp time, we found that at least 120 min of aorta-cross-clamp time on cooling temperature of 7℃ or 23℃ was the optimal condition for maximizaing the differences of survival rate between the groups. When aorta-cross-clamp was continued for 120 min on cooling temperature of 7℃ the measured functional parameters (heart rate left ventricular pressure, maximum dp/dt of LVP) showed descerte difference of recovery rate between the groups. The survival rate was best when low K^(+) solution was used without verapamil. The high K^(+) solution without verapamil showed best recovery of the measured functional parameters.
In the above conditions, addition of verapamil was not helpful for myocardial protection from induced global ischemic of reperfused isolated rat hearts.
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